The Google Maps Navigation app for Android received an update in December of 2010 that allows mobile devices to cache routes and the surrounding areas. In this update users can create and navigate a route without Internet connection, but users cannot currently enter a new destination and navigate to that location. An upgrade could allow for navigation without being in the WiFi zone. This feature will also be introduced on a future Windows 7 phone. The direction system will be giving turn-by-turn directions with the help of the Nokia’s Ovi Maps app. So, these could be a move towards negating a competitive edge on the part of Goggle. If this system turns out to become a regular feature of smartphones, it could put a serious dent in the stand alone GPS unit market, since consumers are unlikely to shell out $200 for something that they can get for free on their phone. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. OnStar, Google Partner to Expand Turn-by-Turn Navigation © 2010 PhysOrg.com Citation: Google Maps Navigation soon to be available offline (2011, June 9) retrieved 18 August 2019 from https://phys.org/news/2011-06-google-offline.html (PhysOrg.com) — All About Phones, a Dutch-based tech site has released information that implies that Google Maps Navigation will have an offline version before the end of the summer. The information, which is only a rumor at this point, may well be true, when you consider some of the technological advances that make this possible.
Explore further Isolation chemists have proposed that paracaseoline A arose through a Diels Alder [4+2] cycloaddition of an alpha-alkenylbutenolide. In all of these studies the researchers completed both the Diels-Alder cycloaddition and dehydration reaction in a single operation under harsh conditions (110oC). The assumption was that the initial dimerization proceeded via an endo transition state geometry. The harsh conditions that were required to complete this process gave rise to the idea that there is a naturally-occurring enzyme in the mangrove plant to catalyze this dimerization (a Diels-Alderase).Wang and Hoye report that the dimerization of the alkenylbutenolide precursor can occur through milder conditions than the typical 110oC reported in the literature and that the precursors interact through an exo orientation rather than the reported endo orientation. This means that in order to arrive at the relative configuration of the natural product, one of the carbon atoms undergoes an epimerization. Wang and Hoye provide compelling evidence that this epimerization occurs through a keto-enol tautomerization and subsequent interaction with the solvent.To prove that the cycloaddition occurs through an exo transition state, Wang and Hoye first investigated an analog to paracaseolide A that has shortened methyl chains rather than the dodecyl alkyl chains. After verifying that their synthetic analog behaved similarly to the naturally-occurring paracaseolide A under the harsh synthetic conditions mentioned in the literature, they tested whether they could obtain product using milder conditions. They were able to isolate the exo Diels-Alder adduct (pre-dehydration intermediate) by reacting the butenolide precursor at 35oC, neat, for six days. The authors verified that it was the Diels-Alder adduct using X-ray crystallography. They also verified that the dimerization step must have proceeded through an exo orientation. DFT studies showed that the transition state leading to the exo Diels-Alder adduct was lower in energy than that of the endo transition state. Furthermore, tests in which the alkyl truncated analog and the analogous Diels-Alder adduct with the dodecyl alkyl chains in place (which could also be formed under ambient conditions) were mixed showed that the reaction via the exo pathway is not reversible.Wang and Hoye believe that the exo adduct is preferred over the endo adduct because the geometry of lowest energy transition state is C2-symmetric. The product is formed through a pathway known as a bis-pericyclic process, passing through a transition state in which the two possible modes of cycloaddition [4+2] and [2+4] have merged. This kind of C2-symmetric, bis-pericyclic assembly has been proposed to be operative in the formation of other simpler compounds and to account for their stereochemistry (e.g., dicyclopentadiene), but not for a natural product, here paracaseolide A.Since one of the four fused rings in the isolated exo adduct is open (a keto acid), Wang and Hoye explored whether reaction through the ring-opened tautomer of the precursor hemiacylal was a possible route for the naturally occurring synthesis. It turns out that this route may be a possibility as it also yields an exo analog for its product. Finally, optical studies suggest that naturally occurring paracaseolide A is racemic just as the synthetic product is. If this is the case, then the naturally occurring reaction likely did not proceed via an enzymatic pathway. Enzymes typically produce an excess of one enatiomer.All of these experiments provide evidence that naturally occurring paracaseolide A is likely formed through a different reaction mechanism than what has been presented in the published literature. The synthesis of paracasolide A does not have to proceed via dimerization under harsh conditions producing an endo Diels-Alder adduct, but likely proceeds through a bis-pericyclic [4+2] dimerization. The mild nature of the conditions required for the dimerization as well as the racemic nature of the naturally produced paracaseolide A are consistent with the proposition that this spontaneous dimerization occurs in nature and that dimerization does not require catalysis by a Diels-Alderase enzyme. Journal information: Nature Chemistry Citation: Researchers provide evidence for a non-enzymatic pathway to produce paracaseolide A (2015, July 14) retrieved 18 August 2019 from https://phys.org/news/2015-07-evidence-non-enzymatic-pathway-paracaseolide.html Researchers achieve enzyme-catalyzed Diels-Alder reaction More information: “Diels-Alderase-free, bis-pericyclic, [4+2] dimerization in the biosynthesis of (+/-)-peracaseolide A” Tao Wang and Thomas R. Hoye, Nature Chemistry, DOI: 10.1038/nchem.2281AbstractThe natural product paracaseolide A is a tetracyclic dilactone containing six adjacent stereocentres. Its skeleton occupies a unique structural space among the >200,000 characterized secondary metabolites. Six different research groups have reported a chemical synthesis of this compound, five of which used a thermal, net Diels–Alder [4+2] cycloaddition and dehydration at 110 °C to access the target by dimerization of a simple butenolide precursor. Here, we report that this dimerization proceeds under much milder conditions and with a different stereochemical outcome than previously recognized. This can be rationalized by invoking a bis-pericyclic transition state. Furthermore, we find that spontaneous epimerization, necessary to correct the configuration at one key stereocentre, is viable and that natural paracaseolide A is racemic. Together, these facts point to the absence of enzymatic catalysis (that is, Diels–Alderase activity) in the cycloaddition and strongly suggest that a non-enzyme-mediated dimerization is the actual event by which paracaseolide A is produced in nature. © 2015 Phys.org (Phys.org)—Paracaseolide A is a naturally occurring compound found in the Chinese mangrove plant (Sonneratia paracaseolaris). Among its abilities, it inhibits an important enzyme in the cell cycle progression and affects regulation of the insulin pathway. What is perhaps most fascinating about this compound is its structure. Tao Wang and Thomas R. Hoye from the Department of Chemistry at the University of Minnesota provide compelling evidence that paracaseolide A proceeds via a different reaction mechanism that what has been reported by several groups in the literature. Specifically, they test whether the reaction proceeds via the spontaneous dimerization of a hydroxybutenolide precursor. Their work appears in Nature Chemistry. Structure and previous syntheses of paracaseolide A. Credit: Tao Wang & Thomas R. Hoye, Nature Chemistry (2015) doi:10.1038/nchem.2281 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Justice Rajiv Shakdher said Pillai has a fundamental right to travel abroad and also she has every right to hold a different opinion on development policies and this cannot be the sole ground to restrict her movement.Besides quashing the look out circular (LOC) issued against her by the Intelligence Bureau (IB), the court also asked the government to remove her name from the database of individuals barred from leaving the country. Though the court declined to order inquiry against the officials involved in her offloading, it directed Bureau of Immigration to expunge the endorsements made on the activist’s passport while offloading her from an aircraft on January 11 while she was going to London to make a presentation before British MPs on an alleged human rights violation at Mahan in Madhya Pradesh. Also Read – Need to understand why law graduate’s natural choice is not legal profession: CJI“…The core aspect of democracy is the freedom of an individual to be able to freely operate, within the framework of the laws enacted by Parliament. The individual should be able to order his or her life any way he or she pleases, as long as it is not violative of the law or constitutes an infraction of any order or direction of a duly constituted court, tribunal or any statutory authority for that matter.“Amongst the varied freedoms conferred on an individual (the citizen), is the right of free speech and expression, which necessarily includes the right to criticise and dissent. Criticism, by an individual, may not be palatable, even so, it cannot be muzzled,” the court said. “There was no basis for the government to issue an LOC against her. The decision taken to detain her at the airport on January 11, 2015 in my opinion, was illegal being violative of the Pillai’s right under Article 21 and 19(1)(a) of the Constitution,” the court added.
Kolkata: A team of doctors under the banner of Bengal Nursing Home and Hospital association on Monday met senior police officers in the district demanding arrest of the hooligans, who had ransacked a portion of a private nursing home in Duttapukar area of North 24-Parganas.The district police are yet to arrest the culprits, who had carried out the attack triggering tension among the patients undergoing treatment. The incident occurred on last Saturday when a group of people went on rampage, ransacking Seva Sadan nursing home in Duttapukur. Police reached the spot and brought the situation under control. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedIt was alleged that the miscreants also looted some important documents and a cheque book.Police said one Sourav Pal (26), a resident of Kalachandpara area was taken to the nursing home after he complained of fever. The doctors in the nursing home urged the family members of the victim to shift the patient to a city hospital as his condition deteriorated following his admission on June 24. But the family members allegedly turned a deaf ear to the appeal of the nursing home authorities. On July 4, the nursing home authorities forced the family members of the patient to take him to RG Kar Medical College and Hospital. The patient died in RG Kar Medical College and Hospital on Sunday after being treated for the past few days. Also Read – Naihati: 10 councillors return to TMC from BJPThe incident had triggered violence when some of the family members of the victim backed by some local hooligans attacked the staff members of the nursing home. The nursing home authorities lodged a specific complaint at the local police station against 5 persons, who had led the attack.A team of doctors led by Dr Goutam Mistri and Dr NB Kanjilal met the district police officers and urged them to arrest the accused. A detailed probe has been initiated.
Kolkata: Chief Minister Mamata Banerjee took a dig at the Centre and said that fresh appointments should take place to reduce the pendency of cases before the courts and bring down the “sufferings” of the common man.Speaking at the foundation stone laying programme of the new complex of the Calcutta High Court at New Town on Wednesday, the Chief Minister said: “There are many pending cases. But as I gathered from the Chief Justice that there are no appointment-related pending works here. However, there are many in Delhi.” Chief Justice of Calcutta High Court Justice Jyotirmoy Bhattacharya was also present at the event. Also Read – Rain batters Kolkata, cripples normal life”I would like to mention that if the infrastructure is not developed and if vacancies are not filed up then the ultimate sufferers will be the common man. There are lakhs of cases and it would take 50 to 100 years for them to be resolved,” Banerjee said adding that the Government of India needs to work with the Supreme Court and High Courts with proper coordination in this connection. While speaking about her government’s initiative taken to develop the necessary infrastructure, the Chief Minister said: “Jalpaiguri Circuit Bench is almost ready. It was a long-pending demand of the locals. A large section of people from North Bengal will be benefitted with the setting up of the Jalpaiguri Circuit Bench.” Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedWhile speaking about the new complex of the Calcutta High Court at New Town, the Chief Minister maintained that the state government has allotted the land within 24 hours of the proposal given in this connection. “I had called up state Urban Development and Municipal Affairs minister Firhad Hakim and directed Debashis Sen, Chairman and MD of WBHIDCO, to identify a plot for the new complex of the High Court. Within half-an-hour, the land was identified and following subsequent processes, the Cabinet gave its approval,” the Chief Minister said adding that the work has been done out of social responsibility. “We are having a huge loan burden of Rs 48,000 crore. Despite that, the move has been taken up considering a better future for which development of necessary infrastructure is absolutely crucial,” she said. It may be mentioned that the state government gave 10 acres of land in New Town at Re 1 to the Calcutta High Court for construction of the new complex. She further said that besides the High Court, steps would also be taken for the development of the infrastructure of the district and sub-divisional courts. “But it would not be possible to carry out the entire work in one go. So the work will be taken up in phases,” the Chief Minister added.
Darjeeling: North Bengal was a witness to sporadic violence on Wednesday, with BJP calling a 12-hour state-wide bandh. However, life was normal in the Darjeeling and Kalimpong Hills, with the bandh evoking no response at all.Despite being an ally of BJP, the Gorkha Janmukti Morcha had earlier declared that they would not support the bandh.”Last year, during the agitation, 13 people had died in the Hills and yet the BJP remained a silent spectator. They did not utter a single word. They have never been sincere towards the Hills and have always indulged in vote bank politics. We will not support the BJP bandh. Darjeeling and Kalimpong have been declared as a strike-free zone,” stated Binay Tamang, president, Gorkha Janmukti Morcha. Also Read – Rain batters Kolkata, cripples normal lifeMeanwhile in the plains of the district, the day started off with shops and business establishments opening and vehicles plying normally. Later during the day, a BJP rally went around town, forcing shops to down shutters. A bus traveling from Cooch Behar to Siliguri was vandalised by bandh supporters.Throughout the day there were reports of sporadic violence from different areas of Siliguri and New Jalpaiguri. 11 vehicles were vandalised. Stones were pelted on shops that were open.Around 90 persons were arrested from all over the Siliguri Police Commissionerate area.In Cooch Behar, state buses were vandalised. Police had to resort to firing tear gas shells in Mekhligunj. There were reports of sporadic violence in Malda as well.
With Christmas around the corner, the holiday season has officially arrived for travel lovers. While vacationing, clean and hygienic bathrooms must always be your priority and for this, keep in mind a few basic steps like using tissues while touching the doorknob, says an expert.First and foremost, avoid touching the toilet doorknob with bare hands. Door knobs carry germs from multiple sources and may cause infections. Try using a tissue paper for holding the knob from outside as well as inside before heading out or going in.Take care of your personal belongings. Germs touching your hands can be easily washed out but once they transmit to your belongings such as phone, handbags, etc, they might infect you. Always prefer an Indian seat toilet instead of the western style to avoid any direct contact with the toilet surfaces. In case you can’t find one, hover over the seat without skin contact or make sure that you wipe the toilet seat before sitting on it.Flush it, turn around and get out of the toilet. The probability of getting infected with air-borne germs and bacteria while flushing is very high. Always close the lid before you flush, take a small tissue to press the flush button and exit the place quickly.Avoid the use of hand dryer, as the hot air has the ability to spread the germs present in the air around. To avoid getting infected use a paper towel to dry them. In the end, use a hand sanitiser and you are good to go!
Kolkata: Miscreants stole ornaments worth several lakh rupees from a temple in the Kidderpore area on Saturday night. On Sunday morning, some ‘sebayat’ identified the theft and reported the matter to the police.According to locals, some ‘sebayat’ of Panchanan temple at Watgunj found a portion of the temple’s roof to be partly broken on Sunday. Some wooden sticks with iron hooks at the end were found lying on the roof. After being informed sleuths from Watgunj police station and anti-burglary section visited the incident spot. Also Read – Rain batters Kolkata, cripples normal lifeSources informed that police found several footprints on the roof. It is suspected that there were more than one person involved in the theft. During a probe police found some wooden sticks with iron hooks attached to it. Preliminary investigation revealed that the thieves tried to enter the main temple by breaking a portion of the wall from the roof. As they failed to create sufficient space to enter the temple, thieves used wooden sticks to steal the ornaments from a ventilation space at the temple. Some of the ornaments were found on the temple floor as they might have fallen from the iron hooks while thieves were trying to steal. Later, the scientific wing of police along with some forensic experts visited the place. It is suspected that the thieves might have kept a watch on the temple for a few days. The sleuths have collected footages from the CCTV cameras installed at the temple premises. Footages from other CCTV cameras in the area will be checked as well to get any clue about the crime.